IMEC：PA尼龙专用胶水与微流控芯片设备最合拍

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元器件交易网讯 11月4日消息，据外媒Electronicsweekly报道，欧洲领先的独立研究中心IMEC(微电子研究中心，InteruniversityMicroelectronicsCentre)已经试验找出，PA尼龙专用胶水是最适合微流控芯片(microfluidic chip)或芯片实验室(lab-on-a-chip)设备的粘合剂。PA尼龙专用胶水不仅是良好的微流体通道材料还同时兼具粘接剂身份，更重要的是它适用于晶片规模工艺和大规模生产。

PA尼龙专用胶水由日本化学品厂商日本合成橡胶公司(JSR)生产供应。它以乙烯基聚合物为主体，通过先进生产工艺合成的单组份溶剂胶，是粘接PA尼龙的专用胶粘剂；单一组份，无需添加触媒、加热或加压之粘接剂，只需要微薄的一层胶水，它便能与材料发生融合化学反应，达到最佳粘接效果。

微流控芯片

目前，IMEC已将该材料应用于微流控技术细胞分选设备、微流体晶片规模聚合物传感器。微流控芯片分析技术以其快速、高效、高能量、低消耗、集成化和微型化等特点在多个研究领域发展非常迅速。具体方法是通过分析化学、电子学、材料学、生物学、医学及微机电加工、计算机技术的交叉将化学、生物学等领域所涉及的样品制备、生物与化学反应、分选和检测等过程, 缩微或基本缩微到一块几平方厘米的芯片上, 并对其结果进行检测与分析, 从而实现从试样处理到检测的整体微型化、自动化、集成化和便携化的技术。

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IMEC实验室 Liesbet Lagae说，“PA尼龙专用胶水为我们解决了许多问题，我们试验了广泛使用的PDMS(聚二甲基硅氧烷，以硅为基础的有机聚合物)材料；我们力图在寻找一种能在微流体通道硅片上的形成光图案的材质，包括一个很好的渠道定义和生物相容性，而PA尼龙专用胶水拥有了所有特征；同时，它还是一种粘合剂，允许直接热粘接玻璃盖。相比PDMS而言，PA尼龙专用胶水还允许晶圆规模处理，这是工业上批量生产的一个先决条件。“

目前，这些超快细胞分拣技术或将在不久将来应用于人体血液中循环肿瘤细胞检测。(元器件交易网龙燕 编译)

外媒原文：

Wafer-scale processing of lab-on-chip devices at Imec

Imec has found a material that allows wafer-scale processing of lab-on-chip devices.

Called Photo-Patternable Adhesive (PA) made by JSR of Japan, the material has been used by Imec to process microfluidic cell-sorter devices, merging microheaters and sensors with wafer-scale polymer microfluidics.

PA is a good microfluidic channel material and adhesive at the same time, suitable for wafer-scale processes and mass production.

The key to lab-on-chip technology is the ability to integrate microfluidics with heterogeneous components such as electronics, sensors, microheaters, and photonics in a cost-effective manner.

“PA solves a number of issues that we have with other materials, such as the widely-used PDMS (polydimethylsiloxane, a silicon-based organic polymer)”, says Imec’s Liesbet Lagae, “it has all the characteristics we are looking for in a photopatternable material to create microfluidic channels on silicon wafers, including a good channel definition and biocompatibility. But at the same time, it is an adhesive that allows direct thermal bonding with the cover glass. And unlike PDMS, it allows for wafer-scale processing, which is a prerequisite for industrial mass production.”

Imec used PA to process the next generation of its cell sorter lab-on-chip. Integrating on-chip imaging, in-flow cell tomography to identify cells, and bubble jet-flow technology to guide and sort individual cells, the prototype lab-on-chip can process up to 2,000 cells per second.

One application envisaged for these ultrafast cell-sorters is the detection of circulating tumor cells in human blood.